Trinidad Sanchez, Jr. was born in Pontiac, Michigan on June 15, 1943, the ninth of ten children born to Sofia Sánchez and Trinidad V. Sánchez, Sr., also a poet.
Sanchez entered the Society of Jesus as a Jesuit brother in Detroit, Michigan, where he worked with young offenders and prison inmates. Remaining in the order for 27 years, Sanchez left the brotherhood but continued to work in prison ministry for an additional five years. In 1992 he moved to San Antonio, Texas to live with longtime friend Regina Chávez, whom he married on Nov. 26, 1993. From the late nineties until 2003 the couple lived in Denver, Colorado where they opened Cafe Taza, a coffee shop showcasing spoken-word performances. In 2003 the couple returned to San Antonio, where the poet spent his final years.

